超滤膜分离技术在维生素B_(12)生产中的应用

Application of Ultrafiltration Membrane in Production of Vitamin B_(12)

采用Ultra-flo超滤系统去除不经预处理的维生素B_(12)发酵液中残留的菌丝体和蛋白质等杂质。用截留分子量为10万的Ultra-flo膜过滤维生素B_(12)发酵液,滤液质量高,平均膜通量可达到122.52 L/m^(-2)·h^(-1),膜通量衰减较慢,被污染的膜经清洗后与新膜没有明显的差异,说明Ultra-flo超滤系统处理能力强且可长时间稳定运行。该超滤系统现已在华北制药集团威可达公司成功应用。

Mycelium, protein and other impurities in non-pretreated broth of Vitamin B12 were removed by Ultra-flo UF system.Filter broth of Vitamin B12 was filtered with MWCO of 10 million of Ultra-flo membrane, filtrate quality was higher, average membrane flux can reach 122.52 L / m2· h^-1,flux decay is slower.After washing, contaminated membrane has no significant difference with the new film.Ultra-flo UF system has strong processing capability with a long and stable operation.The ultrafiltration system has successful applicated in the North China Pharmaceutical Group Corporation.