CD38在139例儿童急性淋巴细胞白血病中的表达及其临床意义

Clinical significance of CD38 expression in childhood acute lymphocytic leukemia

目的探讨CD38在儿童急性淋巴细胞白血病(ALL)中的表达及其临床意义。方法用流式细胞仪检测139例ALL患儿的细胞免疫分型。根据CD38的表达情况,将139例ALL患儿分成CD38阳性组(n=31)与CD38阴性组(n=108),并对两组的临床资料及首次化疗缓解情况进行比较分析。结果 139例ALL患儿中CD38阳性31例,阳性率为22.30%。CD38阳性组年龄、性别、骨髓中幼稚细胞比例、外周血白细胞数、红细胞数、血红蛋白含量、血小板数、出血例数、首次化疗完全缓解例数与CD38阴性组比较差异均无统计学意义(P>0.05),但两组肝大、脾大、淋巴结大例数比较差异均有统计学意义(P<0.05)。结论 CD38的表达有利于ALL患儿病情的判断,但不能作为判断ALL患儿预后的独立指标。

Objective To explore the clinical significance of CD38 expression in childhood acute lymphocytic leukemia（ALL）.Methods The expression of CD38 and immunophenotype in 139 cases with ALL were analyzed by flow cytometry.According to the expression of CD38,all the cases were divided into CD38 positive expression group（n=31）and CD38 negative expression group（n=108）.The clinical feature of the two groups and complete remission rates of the first chemotherapy were compared.Results The positive expression of CD38 in 139 cases with ALL was 31 cases（22.30%）.The results showed that CD38＋-ALL was significantly related with CD38——ALL cells in splenomegoly,lymphadenopathy and hepatomegaly.There was no relationship between CD38 expression and other indicators of ALL.The complete remission rates of the CD38＋-ALL group and CD38——ALL group had no significant difference.Conclusion The expression of CD38 is helpful for the condition of ALL in children.But it cannot be as a independent prognostic indicator in ALL.