溶血磷脂酸、氧化型低密度脂蛋白与不同类型脑梗死的关系

Association between lysophosphatidic acid,oxidized lowdensity lipoprotein and subtypes of cerebral infarction

目的通过测定不同类型急性脑梗死患者血浆中的溶血磷脂酸(LPA)、氧化型低密度脂蛋白(ox-LDL)水平,探索两者与不同临床类型脑梗死的关系。方法选择发病3 d以内的急性脑梗死患者123例,分为初发性与复发性脑梗死组,进展性与非进展性脑梗死组,轻、中、重型脑梗死组。选择同期住院的非缺血性脑血管病患者50例为对照组。所有研究对象均采用改良的无机磷定量方法测定LPA,ELISA法测定ox-LDL。结果 LPA、ox-LDL水平脑梗死组高于对照组,复发组高于初发组,进展组高于非进展组,重型组高于轻型组,差异均有统计学意义(P<0.05)。结论急性脑梗死患者LPA、ox-LDL水平增高,与脑梗死的发生、进展及严重程度相关。

Objective To investigate the relationship between the concentration of lysophosphatidic acid（LPA） and oxidized lowdensity lipoprotein（ox-LDL） in blood and subtypes of cerebral infarction（CI）.Methods One hundred and twenty-three patients who were diagnosed as CI within 3 days after the attack.All the patients were divided into subgroups：once and once more CI,progressive and non-progressive CI,light,medium and severe CI.At the same time 50 patients who without ischemic cerebrovascular disease were selected as control group.All the subjects were examined the levels of lysophosphatidic acid and oxidized lowdensity lipoprotein.Results The levels of LPA and ox-LDL in the patients of the CI group were significantly higher than those in the control group（P0.05）,and once CI group significantly higher than once more CI group,progressive CI group significantly higher than non-progressive CI group,severe CI group significantly higher than light CI group.Conclusion The levels of LPA and ox-LDL in the patients of CI are significantly high.the levels are correlated with subtypes of CI.