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miRNA与缺血性疾病中的血管新生 被引量：1

MicroRNAs and angiogenesis on ischemic diseases
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摘要 MicroRNAs（miRNAs）是存在于真核生物中一类长度约为20~24 nt的非编码小分子单链RNA,可调控多种基因的表达。研究发现,缺血性损伤组织中一系列的miRNAs表达发生了明显变化,且其改变可显著影响缺血组织的血管新生。 MicroRNAs（miRNAs） is a class of 20~24 nt non-coding RNAs that regulate gene expression through posttranscriptional repression or mRNA degradation in a sequence-specific manner.It was reported that miRNAs have an important role in the regulation of new blood vessels.The miRNAs associated with therapeutic angiogenesis and the latest information on mechanism and clinic application of this novel therapy are reviewed.
作者 吴珏 刘芬 汪泱
机构地区 南昌大学第一附属医院泌尿外科研究所
出处 《基础医学与临床》 CSCD 北大核心 2011年第1期93-96,共4页 Basic and Clinical Medicine
基金 国家自然科学基金(30960385)
关键词 MIRNAS 血管新生 缺血 miRNAs angiogenesis ischemia
分类号 R363 [医药卫生—病理学]
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参考文献17

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同被引文献13

  • 1Yoh Takuwa,Yasuo Okamoto,Noriko Takuwa,Kazuaki Yoshioka.Roles of sphingosine-1-phosphate signaling in angiogenesis[J].World Journal of Biological Chemistry,2010,1(10):298-306. 被引量：5
  • 2Yang H,Kim C,Kim MJ,et al.Soluble vascular endothelial growth factor receptor-3suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer. Molecular Cancer . 2011
  • 3Eto H,Suga H,Inoue K,et al.Adipose injury-associated factors mitigate hypoxia in ischemic tissues through activation of adipose-derived stem/progenitor/stromal cells and induction of angiogenesis. American Journal of Pathology . 2011
  • 4Willis LM,El-Remessy AB,Somanath PR,et al.Angiotensin receptor blockers and angiogenesis:clinical and experimental evidence. Clinical Science Lond . 2011
  • 5Sun T,Cao H,Xu L,et al.Insulin-like growth factor binding protein-related protein1mediates VEGF-induced proliferation,migration and tube formation of retinal endothelial cells. Current Eye Research . 2011
  • 6Segers VF,Revin V,Wu W,et al.Protease-resistant stromal cell-derived factor-1for the treatment of experimental peripheral artery disease. Circulation . 2011
  • 7Stabile E,Burnett MS,Watkins C,et al.Impaired arteriogenic response to acute hindlimb ischemia in CD4-knockout mice. Circulation . 2003
  • 8吴庆华,杨培.再谈严格掌握下肢动脉硬化闭塞性疾病手术和血管腔内治疗的指征[J].中华临床医师杂志（电子版）,2009,3(2):4-5. 被引量：6
  • 9肖华,迟路湘.血管再生研究的现状及进展[J].西南国防医药,2009,19(9):952-954. 被引量：4
  • 10虞桂平,沈振亚,余云生,郭世强,陈一欢,胡雁秋.自体骨髓动员对急性缺血心肌血管再生的影响[J].中国组织工程研究与临床康复,2010,14(19):3499-3502. 被引量：1

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基础医学与临床
2011年 第1期

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