射频消融术联合TACE治疗肝癌

Radiofrequency ablation combined with transcatheter arterial chemoembolization in treatment of liver cancer

目的探讨射频消融术(RFA)联合经导管肝动脉化疗栓塞术(TACE)对肝癌的治疗效果。方法对36例肝癌患者共48个病灶行CT引导下RFA治疗,病灶直径1.50～9.50cm。所有患者术前均接受过一次或多次TACE或TAE治疗,治疗术前术后均行CT、MRI等影像学检查,并定期随访。结果术后肿瘤完全损毁率为64.58%(31/48),部分损毁率为22.92%(11/48),复发率为12.50%(6/48)。术后相关肿瘤指标AFP和CEA均有不同程度下降。所有病例均未出现严重肝功能损害。结论 RFA是治疗原发性及转移性肝癌安全有效的手段,与TACE联合应用更有助于提高对肝癌的治疗效果。

Objective To observe the efficacy of radiofrequency ablation（RFA）combined with transcatheter arterial chemoembolization（TACE）in the treatment of liver cancer.Methods Thirty-six patients with total 48 liver tumors were treated with CT-guided RFA.The diameter of tumors ranged 1.50—9.50 cm.All patients underwent one or more times of TACE or transcatheter arterial embolization（TAE）before RFA.Preoperative and post-procedural CT or MRI scan were performed in all patients.Results Of 48 tumors,complete necrosis was obtained in 31（64.58%）,local necrosis was obtained in 11（22.92%）and recurrence in 6（12.50%）.The level of AFP or CEA in the patients decreased in various degrees after traetment.No serious hepatic function abnormality was observed.Conclusion RFA is a safe and effective therapy for primary liver cancer and metastasis.RFA combined with TACE can increase the efficacy of liver cancer.