耳蜗电图Sp/Ap面积比在梅尼埃病诊断中的作用

Utility of Sp/Ap curve area ratio electrocochleography in diagnosis of Meniere's disease

目的:比较耳蜗电图中不同指标Sp/Ap的振幅比和面积比对梅尼埃病辅助诊断的敏感性。方法:通过将梅尼埃病患者耳蜗电图中Sp/Ap的振幅比和面积比分别与其正常水平值相比较,试图寻找更敏感的指标来提高耳蜗电图对梅尼埃病的诊断敏感性。结果:35例梅尼埃病患者中有48.6%的患者Sp/Ap振幅比>0.4,若参照10例(20耳)正常人所得Sp/Ap的振幅比参考值范围(高限0.49,95%置信区间),阳性率只有39.1%,参照10例(20耳)正常人所得Sp/Ap的面积比参考值范围(高限1.92,95%置信区间),35例梅尼埃病患者中有28例Sp/Ap的面积比高于1.92,阳性率为77.1%。结论:采用Sp/Ap的面积比能提高对梅尼埃病的诊断敏感性。

Objective：Comparison of the sensetivitity of Sp/Ap amplitude and area ratio in the aid of diagnosis of Meniere＇s disease.Meniere＇s disease was defined by the 1995 American Academy of Otolaryngology-Head and Neck Surgery Committee on Hearing and Equilibrium.Method：The study sample consisted of 35 patients in our hospital, who were undergone tympanic electrocochleography （EcochG）. A control group of 10 patients （20 ears） with normal Sp/Ap ratio and EcochG data were identified. Sp/Ap amplitude and area curve ratios for both group were measured.Result：The traditional upper limit and the upper limit of normal for Sp/Ap amplitude and area curve were respectively 0.4,46 and 1.94. Of 35 patients with Meniere＇s disease, had an abnormal Sp/Ap amplitude ratio,and had an abnormal Sp/Ap area curve ratio; the difference between groups was statistically significant.Conclusion：Sp/Ap curve area curve ratio is more sensitive than conventional Sp/Ap amplitude ratios in diagnosis of Meniere＇s disease.