川崎病患儿血清中性粒细胞激活肽-78和内脂素水平变化及其意义研究

Clinical Significance of ENA-78 and Visfatin and Their Association with Kawasaki Disease

目的探讨川崎病患儿血清中性粒细胞激活肽-78(ENA-78)和内脂素水平的变化及临床意义。方法采用酶联免疫法检测90例川崎病患儿和30例健康体检儿童的血清ENA-78和内脂素水平。结果川崎病组患儿血清中ENA-78水平〔(163±22)ng/L〕明显高于对照组〔(64±12)ng/L〕,内脂素水平〔(32±5)μg/L〕也明显高于对照组〔(17±4)μg/L〕,差异均有统计学意义(P<0.05)。川崎病组中冠状动脉损伤患儿血清ENA-78水平〔(217±30)ng/L〕明显高于冠状动脉正常患儿〔(129±20)ng/L〕,内脂素水平〔(37±5)μg/L〕也明显高于冠状动脉正常患儿〔(28±5)μg/L〕,差异均有统计学意义(P<0.05)。川崎病组患儿血清ENA-78水平与内脂素水平呈正相关(r=0.67,P<0.05)。结论 ENA-78和内脂素水平在川崎病尤其伴冠状动脉损伤时明显升高,可作为判断川崎病冠状动脉损伤的参考指标。

Objective To explore the levels and clinical significance of epithelial neutrophil - aetiving peptide - 78 （ ENA - 78 ）, visfatin in the serum of children with Kawasaki diseases （KD） . Methods Serum level of ENA - 78 and visfatin was measured in 90 children with KD and 30 healthy children by ELISA, and the outcome was estimated in combination with clinical symptoms. Results The serum levels of ENA - 78 and visfatin in children with KD were significantly higher compared with that of the control group （ P 〈 0. 05 ） ; The serum levels of ENA - 78 and visfatin in children of KD with coronary artery lesion （CAL） were significantly higher compared with that of children of KD without CAL （ P 〈 0. 05 ）. In children with KD, the serum levels of ENA - 78 and visfatin had a positive correlation （ r = 0. 67, P 〈 0.05 ）. Conclusion Serum levels of ENA - 78 and visfatin are increased in the acute phase of KD, and are significantly higher in those KD children with CAL. ENA - 78 and visfatin may be used as an important serological indicator of KD with CAL.