个体化综合治疗方案治疗重症急性胰腺炎效果观察

Individualized Comprehensive Therapy in Severe Acute Pancreatitis

目的探讨个体化综合治疗方案治疗重症急性胰腺炎(SAP)的临床效果。方法选取2007年1月—2010年1月我院收治的采用"个体化综合治疗方案"治疗的86例SAP患者为治疗组,同时选取同时期在我院采用常规治疗的74例SAP患者为对照组,对比两组患者的治愈率、住院时间及治疗14 d后急性生理和慢性健康状况评分系统(APACHEⅡ)评分、血和尿淀粉酶、肝肾功能。结果治疗组治愈73例,死亡13例;对照组治愈53例,死亡21例,两组治愈率比较,差异有统计学意义(P<0.05)。治疗组住院时间及APACHEⅡ评分较对照组均明显降低,差异有统计学意义(P<0.05)。治疗组血淀粉酶、尿淀粉酶、丙氨酸氨基转移酶、天冬氨酸氨基转移酶、血肌酐、尿素氮较对照组均明显降低,差异有统计学意义(P<0.05)。结论个体化综合治疗方案治疗SAP效果显著,对各重要脏器有保护作用,值得推广。

Objective To explore the clinical results of individualized comprehensive treatment of severe acute pancreatitis （SAP）. Methods Eighty - six SAP patients given individualized comprehensive therapy were chosen as therapy group, another 74 SAP patients not given that as control group. The cure rates, hospital stay, scores of acute physiology and chronic health evaluation （APACHE II） 14 h after treatment, blood and urinary amylase, liver and renal function were compared between 2 groups. Results Seventy - three patients were cured and 13 died in therapy group, 53 and 21, respectively, in control group, the difference was significant （P 〈0. 05 ）. Hospital stay and APACHE II score were significantly lower in therapy group than in control （ P 〈 0. 05 ） , and the levels of blood and urinary amylase, alanine aminotransferase, aspartate aminotransferase, serum ereatinine, urea nitrogen lower （P 〈0. 05）. Conclusion Individualized comprehensive therapy in SAP, obviously effective with protective effect on all major organs, is worth promoting.