良性前列腺增生药理学研究中的动物模型

Animal models for pharmacological research of benign prostatic hyperplasia

良性前列腺增生(BPH)是老年男性的常见病,但目前病因尚不明了,因此有必要建立合适的动物模型以研究其相关发病机制。本文综述目前BPH药理学研究中的动物模型,重点分析BPH诱导模型、异种移植动物模型、转基因小鼠模型和自发性BPH模型等的特点,探讨各造模方法及其在实际药理学研究中的价值。

Benign prostatic hyperplasia（BPH） is one of the most common diseases affecting elderly men. However, its etiology is not clear yet. It is necessary to develop suitable experimental models to investigate BPH s pathogenesis. This review describes the animal models used in BPH pharmacological research including BPH induction models, xenograft models, transgenic mice models and spontaneous BPH models.