慢性肾衰患者不同透析膜血透时脂质过氧化变化及其临床意义

INVESTIGATION OF LIPID PEROXIDE CONTENT IN CHRONIC RENAL FAILURE PATIENTS HEMODIALYZED WITH DIFFERENT MEMBRANES

为探讨慢性肾衰患者不同透析膜透析时氧自由基的氧化损伤，对维持性血透病人使用铜仿膜、聚砜膜及血仿膜透析，分别检测透析前、后血浆和红细胞脂质过氧化物（ Ｌ Ｐ Ｏ） 、超氧化物歧化酶（ Ｓ Ｏ Ｄ） 及全血谷胱甘肽过氧化物酶（ Ｇ Ｐ Ｘ） 活性，并与健康组对照。结果示铜仿膜透析后红细胞 Ｌ Ｐ Ｏ 显著增加， Ｓ Ｏ Ｄ 活性显著降低，聚砜膜和血仿膜则变化不明显。揭示使用聚砜膜或血仿膜行长期血透可防治患者因氧自由基增加产生的并发症。

Objective: To investigate the possible oxidative injuries to chronic renal failuer patients during hemodialysis with different membranes.Methods:The levels of lipid peroxide(LPO) and superoxide dismutase(SOD) in plasma and red cell,gultathione peroxidase(GPX) in whole blood samples of hemodialyzed patients were examined respectively before and after being hemodialyzed with cupophane,polysulphone and hemophan membranes,and were compared with those of the health controls. Results:There was a significant increase of LPO level and a decrease of SOD activity after being dialyzed with cupophane membrane, while no significant difference was observed in the groups dialyzed with polysulhone and hemophan membranes.Conclusion:The results suggest that the application of polysulphone and hemophan membranes for long term hemodialysis is beneficial to prevent and cure the syndrome caused by the increase of peroxide radicals.