我国药用雄黄的晶体结构鉴定

Validation of the Crystal Structure of Medicinal Realgar in China

采用拉曼光谱和X射线衍射法,结合文献研究鉴定我国药用雄黄的晶体结构为α-As4S4。实验选取我国唯一药用雄黄的基源矿石——湖南石门雄黄矿石及临床药用的饮片、中成药制剂等10批样品为研究对象,测定了其XRD(X-ray diffraction)图谱和拉曼光谱,其特征谱线经全谱拟合获得了PDF(the powder dif-fraction file)号及晶体常数,拉曼光谱解析了其成键情况,并且通过对不同构型雄黄的鉴别,验证了我国药用雄黄的晶体结构。同时,对六种常规方法制备的18批炮制品及含雄黄中成药制剂的研究发现,常规的炮制加工和制剂生产不会造成雄黄晶体结构的变化。该研究结果澄清了我国药用雄黄的化学本质,为雄黄的质量标准制订以及吸收机理研究奠定了基础。

The crystal structure of medicated realgar in China was validated as α-As4S4 by X-ray diffraction and Raman spectroscopy in the present paper.Ten batches of medicinal realgar were analyzed including realgar ore,medicinal realgar powder,and prepared Chinese medicine.Identification of two As4S4 polymorphs confirmed that the crystal structure of medicated realgar in China is α-As4S4.Studies on 18 batches of preparative realgar powder showed that processing of realgar can not change the crystal structure of realgar.