清热凉血解毒法治疗寻常型银屑病血热证的重复测量分析

The Repeated Measures Analysis for Clinical Effectiveness of removing pathogenic heat from the blood in treating psoriasis vulgaris with Blood-Heat Syndrome

目的:客观评价清热凉血解毒法治疗寻常型银屑病血热证的临床疗效,并分析临床疗效趋势及特点。方法:采用重复测量的临床试验设计方法,观察寻常型银屑病血热证患者,采用清热凉血解毒法治疗后,PASI评分的变化特点,从中提炼治疗中医药治疗银屑病的优势所在及时间变化趋势。结果:71例入组患者中痊愈4例,显效15例,有效44例,无效8例;痊愈率6%,显效率21%,总有效率为89%。经重复测量分析,患者PASI积分的变化在治疗过程中呈平稳下降趋势。结论:清热凉血解毒法效果确切,而且通过重复测量的分析方法进一步明确了在治疗过程中的皮损变化特点及趋势,动态地描述了病情与治疗时间的相关性,为以后的相关研究提供了借鉴。

Objective：To evaluate the clinical efficacy of removing pathogenic heat from the blood in treating psoriasis vulgaris with Blood-Heat Syndrome,and to analysis the trends and characteristics of the clinical efficacy. Methods：Applying repeated measures design and analysis for this trail,to observe the PASI score varying characteristics of psoriasis vulgaris with Blood Heat Syndrome after the treatment of removing pathogenic heat from the blood,and to refine the treatment of the advantages of Chinese medicine treatment of psoriasis location and time trends. Results：71 cases finished the course of treatment; 4 patients（6% ） were cured,15 patients（21% ） were effected excellently,44patients（62% ） has effective results and 8（11% ） patients ineffective. The total effective rates of the three groups are 89% . Through the repeated measures design and analysis,the changes of PASI in the course of treatment showed a steady downward trend. Conclusion：This study proved that there is a good curative effectiveness of treating psoriasis vulgaris by removing pathogenic heat from the blood,further more,applying the repeated measures analysis,we definitude the changing characteristics and trends of the lesions in treating,made a dynamic description of relevance between the disease severity and the treatment time,and gained experience for future allied research.