尿毒清联合结肠透析对慢性肾衰竭非透析患者微炎症状态及肾功能的影响

Effect of Uremic Clearance Granule Combined with Colon Dialysis Against Microinflammation Status and Renal Function in Nondialytic Patients with Chronic Renal Failure

目的:观察尿毒清联合结肠透析对慢性肾衰竭(CRF)非透析患者微炎症状态及肾功能的影响。方法:选择本院CRF非透析患者45例,随机分为治疗组和观察组,并设健康对照组,治疗组给予尿毒清联合结肠透析治疗2个月。治疗前后测定患者血清C-反应蛋白(hs-CRP)、白细胞介素6(IL-6)、肿瘤坏死因子(TNF-α)水平。结果:两组CRF患者共45例治疗前的hs-CRP、IL-6、TNF-α水平均高于正常对照组(P<0.01)。hs-CRP、IL-6、TNF-α与血肌酐(SCr)呈正相关(P<0.001)与肌酐清除率(CCr)呈负相关(P<0.001)。2个月后治疗组hs-CRP、IL-6、TNF-α水平均明显下降,与观察组比较差异有显著性。结论:CRF患者存在微炎症状态,尿毒清联合结肠透析能改善患者的微炎症状态,起到延缓肾衰竭速度及保护残存肾功能的作用。

Objective：To investigate the effect of uremic clearance granule combined with colon dialysis against microinflammation status and renal function in nondialytic patients with chronic renal failure（CRF） . Methods：Forty-five nondialytic patients with CRF were randomly allocated to treatment group and observation group,another 20 healthy volunteers were served as control group. Patients in treatment group were administered with uremic clearance granule combined with colon dialysis for 2 months. The serum of high sensitivity C-reactive protein （hs-CRP） ,innterleukkin -6（IL -6） ,tumor necrosis factor-α（TNF-α） were measured respectively before and after the treatment. Results：The serum of hs-CRP,IL-6,TNF-αin forty-five patients with CRF before therapy were significantly higher than in control group （P 0. 01 respectively） . hs-CRP,IL-6,TNF-αhad significant positive relation with SCr（P 0. 001） and inversely relation with CCr （P 0. 001） . The serum of hs-CRP,IL -6,TNF-αin treatment group patients were significant lower than those before therapy. There were a significant difference with treatment group and observation group after treatment. Conclusion：There was microinflammation status in patients with CRF,uremic clearance granule combined with colon dialysis could delayed the rate of renal failure and protected renal function through improved microinflammation status.