摘要
以改进型Franz扩散池为经皮吸收研究装置,pH6.8磷酸缓冲液为接收液,裸鼠皮肤为实验皮肤,HPLC法测定青藤碱含量,采用均匀设计法从氮酮、丙二醇、油酸中选择适宜的经皮吸收促进剂及最佳配比。结果:氮酮、丙二醇的含量分别为6%、10%时,青藤碱有最大的经皮速率常数。氮酮与丙二醇以一定比例组成复合体使用时,对青藤碱的经皮吸收有较好的促进作用。
Using uniform design,the selection of transdermal enhancers for sinomenine from various proportion of azone,propylene glycol and oleic acid was studied using improved Franz cell for equipment of absorption study,pH 6 8 phosphate buffer as absorption solution,skin of hairless mice as experimental skin,HPLC for measuring the content of sinomenine.Result:the transdermal speed constant of sinomenine was the hgihest while the contents of azone and propylene glycol is 6% and 10%,respectively.The result indicates that a certain proportion of azone and propylene glycol can improve transdermal absorption of sinomenine.
出处
《中国实验方剂学杂志》
CAS
1999年第5期3-5,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家中医药管理局重点资助