青藤碱PVA膜中经皮吸收促进剂的选择

Selection of Transdermal Enhancers for Sinomenine in PVA Layer

以改进型Ｆｒａｎｚ扩散池为经皮吸收研究装置，ｐＨ６．８磷酸缓冲液为接收液，裸鼠皮肤为实验皮肤，ＨＰＬＣ法测定青藤碱含量，采用均匀设计法从氮酮、丙二醇、油酸中选择适宜的经皮吸收促进剂及最佳配比。结果：氮酮、丙二醇的含量分别为６％、１０％时，青藤碱有最大的经皮速率常数。氮酮与丙二醇以一定比例组成复合体使用时，对青藤碱的经皮吸收有较好的促进作用。

Using uniform design,the selection of transdermal enhancers for sinomenine from various proportion of azone,propylene glycol and oleic acid was studied using improved Franz cell for equipment of absorption study,pH 6 8 phosphate buffer as absorption solution,skin of hairless mice as experimental skin,HPLC for measuring the content of sinomenine.Result:the transdermal speed constant of sinomenine was the hgihest while the contents of azone and propylene glycol is 6% and 10%,respectively.The result indicates that a certain proportion of azone and propylene glycol can improve transdermal absorption of sinomenine.