抗菌药物治疗的新模式—毒力因子靶向治疗

Targeting Virulence:a New Paradigm for Antimicrobial Therapy

各种耐药细菌的出现和蔓延,亟需开辟新的抗感染途径。抗细菌毒力靶向药物治疗能选择性地遏制目标菌的毒素表达、毒素传递、调节毒力表达、黏附作用等,有效预防和治疗多种感染疾病。这类药物并不直接影响菌体的存亡,故能有效降低细菌耐药性的传播和流行,弥补现行抗感染药物的不足之处,是研发抗感染新药的新途径。

The emergence and increasing prevalence of bacterial strains that are resistant to available antibiotics require the discovery of new therapeutic approaches.Targeting bacterial virulence is an alternative approach to antimicrobial therapy that offers promising opportunities to inhibit of toxin function,bacterial toxin delivery,the regulation of virulence expression,adhesion and so on.These drugs can represent a new paradigm for the clinicians to prevent and treat infectious diseases more effectively,make up for existing inadequacies of anti-infection drugs and develop a new way for anti-infective drugs,while they do not affect the survival of bacteria directly.