摘要
RNA干扰(RNA interference,RNAi)是由双链RNA(double-stranded RNA,dsRNA)介导的细胞内双链mRNA特异性降解的现象,属于转录后的基因沉默机制。迄今为止,RNAi已经是一种广泛应用于研究基因功能的最新和最有效的方法,并且在治疗人类和动物疾病中也有很大潜力。作者主要综述了RNAi的过程、小RNA的生物发生学及沉默通路的保护和调控。
RNA interference（RNAi） is induced by double-stranded RNA and result in specific degradation of double-stranded mRNA in cell,and it belongs to post-transcriptional gene silencing mechanism.RNAi has been extensively used as a novel and effective tool for functional genomic studies,and has displayed great potential in treating human and animal diseases.The paper aims to summarise the process of RNAi and make statement about biogenesis of small RNAs,safeguards and regulation of silengcing pathways.
出处
《中国畜牧兽医》
CAS
北大核心
2011年第1期92-95,共4页
China Animal Husbandry & Veterinary Medicine
基金
国家自然科学基金项目(30972224)
