摘要
近年来耐碳青霉烯类抗生素的肺炎克雷伯杆菌有逐年增多的趋势,其机制主要是碳青霉烯酶的产生,其中又以肺炎克雷伯杆菌碳青霉烯酶最为多见,高产C类头孢菌素酶或超广谱β-内酰胺酶同时合并膜孔蛋白的缺失也逐渐得到重视.耐碳青霉烯类肺炎克雷伯杆菌的控制面临严峻的考验,目前提倡防治相结合的综合措施,积极加强医院管理,严格感染控制措施,同时给予敏感药物治疗,并强调多药联合.本文将讨论肺炎克雷伯杆菌耐碳青霉烯类药物的机制及其防治措施.
In recent years, carbapenem-resistant Klebsiella pneumoniae is increasing year by year.The main mechanism is the production of carbapenemase, especially Klebsiella pneumoniae carbapenemase,highly producing class C cephalosporinase or superspectrum β-lactamase combined with loss of membrane protein is another important mechanism. The control of carbapenem-resistant Klebsiella pneumoniae is faced with a severe test. Recently,it is advocated that combination measures of prevention and treatment,actively strengthening hospital management, strictly making infection control measures,sensitive drug treatment, and multi-drug combination therapy. This article discusses the mechanism and control measures of carbapenem-resistant Klebsiella pneumoniae.
出处
《国际呼吸杂志》
2011年第2期125-128,共4页
International Journal of Respiration
