α-羟基苯甲基取代异喹啉化合物的合成及其对血管紧张素Ⅱ受体的拮抗作用

The Synthesis of α Hydroxylphenylisoquinolines and Their Antagonism towards Angiotensin Ⅱ

合成了１０ 个未见报道的异喹啉衍生物，其化学结构经ＩＲ，１ＨＮＭＲ，ＭＳ及元素分析证实．经大鼠肝膜血管紧张素Ⅱ受体拮抗活性研究表明，其中两个化合物具有一定拮抗活性．

Ten isoquinoline analogs were synthesized and none of them had been reported.Their structures were identified by elemental analysis and IR,MS, 1H NMR spectra.Two of them exhibited antagonism towards angiotensin Ⅱ.