摘要
目的:观察芪龙方对荷瘤小鼠T细胞亚群和自然杀伤(NK)细胞的作用。方法:用615 小鼠移植前胃癌(FC),观察芪龙方(1 000 m g/kg)、阿霉素(1.5 m g/kg)及其联合用药对荷瘤小鼠的T细胞亚群CD+4 、CD+8 数量和NK 细胞的活性、抑瘤作用及体重变化的作用。结果:给药第7、13 天,芪龙方组CD+4 数量明显上升(P < 0.05),CD+8 数量有所升高,但无显著性差异( P> 0.05);联合用药组CD+4 升高,优于对照组及单纯化疗组(P< 0.05)。给药第7、13天,芪龙方组NK细胞活性明显升高( P< 0.05),联合用药组升高趋势优于单纯化疗组,但无显著性差异( P> 0.05)。给药第7、13 天,芪龙方组抑瘤作用分别为25.0% 、40.5% ,联合用药组分别为41.7% 、54.2% 。结论:芪龙方具有直接抑制肿瘤生长。
Objective: To observe the effects of qilong decoction on T lymphocyte subpopulation and natural killer(NK) lymphocyte in tumor bearing mice. Methods:(1) Mice 615 with gastric carcinoma were divided into four groups which were given qilong decoction(1 000 mg/kg) (group A),Adriamycin (ADM)(1.5 mg/kg) (group B) and both at the same time (group D). (2) At seventh,thirteenth day CD + 4、CD + 8and NK cells of each groups mouse were detected and recorded respectively .Results:In group A the quantity of CD + 8 rose markedly(P< 0.05 ),the quantity of CD + 8 also rose somewhat without obvious difference(P< 0.05 );In group C CD + 4 is higher than that of the group D and group B (P< 0.05 ).In group A the activity of NK cell increased obviously (P< 0.05 ),the growing tendency of group C is superior to that of the group B without marked difference (P> 0.05 ); the inhibitive effect on tumor in group A are 25.0% and 40.5% but 41.7% and 54.2% in group C. Conclusion:The qilong decoction can inhibit growth of tumor directly and improve bodys immune function.
基金
国家自然科学基金
关键词
芪龙方
肿瘤
自然杀伤细胞
T细胞亚群
qilong decoction
immune adjustment
inhibitive tumor
natural kiuer cell