红曲霉菌胞外多糖的抗肿瘤活性研究

The Study of Monascus EPS' Anti-tumor Activity

目的:研究红曲霉胞外多糖(Exopolysaccharide,EPS)的抗肿瘤活性,为阐明红曲胞外多糖的药理作用和临床应用奠定基础。方法:红曲霉菌经液体发酵培养后,醇沉提取发酵液中的胞外多糖并测定其含量;建立H22荷瘤小鼠模型,以胞外多糖的抑瘤率、小鼠的相对生长率和各脏器指数为指标,研究红曲胞外多糖的抗肿瘤活性。结果:中剂量100mg/(kg.d)红曲胞外多糖给药组的药理作用比较明显,抑瘤率达到了44.95%。结论:红曲霉胞外多糖有抗肿瘤作用,并且与剂量相关,但不成正向线性比例关系,而在适当给药剂量时所表现的效果比较明显。

Objective： To illuminate the pharmacological effects and clinic application of Monascus EPS by investigating Monascus EPS’ anti-tumor activity.Methods： Monascus was cultured in fermentation liquor,and the Extract Monascus EPS from Monascus by grade alcohol was quantitied.H22 tumor-bearing mice model was established,the anti-tumor activity of Monascus EPS was quantitied by analysing mice relative growth rate,organ index and tumor inhibition rate.Results： The pharmacological effects is significant in medium dose subgroup,the inhibition rate of which is up to 44.95%.Conclusion： There has anti-tumor effect in monascus EPS,which is dose-related.But the effect is not the proportion of positive linear relationship.The effect is significant when the dosage is propriety.