摘要
目的:探讨运脾和络颗粒对糖尿病周围神经病变大鼠血浆β-内啡肽的影响。方法:造模大鼠随机分成正常组、模型组、运脾和络颗粒高、中、低剂量组、甲钴胺组,用酶联免疫法检测运脾和络颗粒对糖尿病周围神经大鼠血浆β-内啡肽的影响。结果:运脾和络颗粒高、中剂量组能明显上调大鼠血浆β-内啡肽(P<0.05)。结论:运脾和络颗粒能上调糖尿病周围神经病变大鼠血浆β-内啡肽,可能是其改善糖尿病周围神经病变的机理之一。
Objective： To explore the effect of Yunpi Granule on plasma β-endorphin in rats with peripheral neuropathy diabetic.Methods： The rats were randomly divided into the control group,the model control group,the high,medium and low dosage of Yunpi Granule groups and western medicine（Methylcobalamin） control group.ELISA was used to observe the effect of Yunpi Granule on plasma β-endorphin in rats with peripheral neuropathy diabetic.Results： Interving groups of Yunpi Granule compared with the model group,the expression of plasma β-endorphin were increased to varying degrees,which medium-dose group was significantly higher（P〈0.05）,followed by high-dose group（P〈0.05）.Conclusion：Through up-regulation on plasma β-endorphin expression is possibly one of the mechanisms of Yunpi Granule in treating peripheral neuropathy diabetic.
出处
《中华中医药学刊》
CAS
2011年第1期125-127,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省科技厅资助项目(2008C24009)
