复方余甘子含片对人唾液分泌型免疫球蛋白A的影响

Effects of Phyllanthus Emblica Compound Tablets to Human Salivary Secreted IgA

目的:通过观察复方余甘子含片对人唾液分泌型免疫球蛋白A(SIgA)的影响,初步探讨其对人体口咽部局部黏膜免疫的调节作用。方法:余甘子中加入黄芪、玉竹、甘草制成口含片。筛选健康人群及慢性咽炎人群含服复方余甘子含片,采集含片前后唾液,ELISA检测唾液中的SIgA含量。结果:健康人群组含服复方余甘子含片两周后,唾液中SIgA含量有升高趋势,并有统计学意义(P=0.012<0.05),而慢性咽炎人群含服复方余甘子含片及对照药物(市售草珊瑚含片)后,唾液SIgA含量虽略有升高,但无统计学意义。结论:复方余甘子含片通过刺激健康人唾液SIgA的分泌,增强人体口咽部局部黏膜免疫,从而对健康人群预防上呼吸道感染性疾病有一定的保健作用。

Objective：Through the observation of the effect about Phyllanthus emblica compound tablets to human salivary secretory immunoglobulin A（SIgA）,and preliminary discuss the regulating action to human oropharyngeal mucous membrane immunity by Phyllanthus emblica compound tablets.Methods：Prepare the Phyllanthus emblica compound tablets by Phyllanthus emblica and Huangqi,Yuzhu,Gancao.Select healthy and chronic pharyngitis people take Phyllanthus emblica compound tablets,and collect the saliva before and after taking the tablets.Then measure the content of salivary SIgA by ELISA.Results：The tablets increased healthy people’s salivary SIgA after taking two weeks（P=0.012〈0.05）.But there is no statistics significance of chronic pharyngitis people’s salivary SIgA after taking the tablets and comparison drug.Conclusion：Phyllanthus emblica compound tablets promote the secretion of salivary SIgA,strengthen the oropharyngeal mucous membrane immunity defence,and defend the infection of upper respiration way in healthy people.