芪芩颗粒联合埃索美拉唑治疗耐药幽门螺旋杆菌相关性溃疡的疗效评价

Astragalus and Baicalin Treatment Esomeprazole Combined Resistance of H.Pylori-related Ulcer Evaluation

目的:评价黄芪和黄芩联合埃索美拉唑治疗耐药幽门螺旋杆菌(Hp)相关性消化性溃疡的疗效。方法:将80例耐药Hp相关性消化性溃疡患者,随机分为治疗组和对照组:治疗组用芪芩颗粒联合埃索美拉唑治疗1周,对照组给予抗Hp标准三联治疗1周,治疗1周后,两组均续服埃索美拉唑治疗3周。记录治疗前后临床症状积分;停药4周后复查胃镜和14C呼气试验,判断溃疡愈合率和Hp根除率;停药6个月后复查14C呼气试验,判断Hp复发率。结果:治疗组主次症状改善明显,治疗前后临床症状积分均显著下降(P<0.01)。对照组胃脘疼痛、烧心泛酸、口苦口臭改善明显(P<0.01),其它症状改善不明显。治疗组和对照组溃疡愈合率分别为(42/46)91.3%和(26/34)76.5%,两组间差异有统计学意义(P<0.05)。治疗组和对照组Hp根除率分别为(39/46)84.9%和(21/34)61.8%,两组间差异有统计学意义(P<0.05)。治疗组和对照组Hp复发率分别为(4/39)10.3%和(6/21)28.5%,两组间差异有统计学意义(P<0.05)。结论:黄芪和黄芩联合埃索美拉唑能有效根除耐药Hp,提高耐药Hp相关性溃疡的临床疗效,降低Hp复发率。

Objective： To evaluate the astragalus and baicalin treatment esomeprazole combined resistance of H.pylori（Hp） related peptic ulcer.Methods：80 patients with resistant Hp related peptic ulcer were randomly divided into treatment and control groups： treatment group,combined with Qi qin particles esomeprazole treatment for 1 week in the control group received standard triple anti-Hp therapy 1 week,1 week after treatment,both groups continued service esomeprazole treatment for 3 weeks.Symptom scores before and after treatment;4 weeks after endoscopy and 14C breath test to determine the rate of ulcer healing and Hp eradication.Review 6 months after stopping 14C breath test to determine Hp recurrence rate.Results：Primary and secondary symptoms of the treatment group improved significantly after treatment,clinical symptom scores were significantly decreased（P〈0.01）.Control group,epigastric pain,heartburn and heartburn,I suffer bad breath improved significantly（P〈0.01）,no obvious improvement of other symptoms.Treatment group and control group were ulcer healing rate（42/46） and 91.3%（26/34） 76.5% difference between two groups was statistically significant（P〈0.05）.The treatment group and control group Hp eradication rate was（39/46） and 84.9%（21/34） 61.8%,difference between two groups was statistically significant（P〈0.05）.Treatment group and control group Hp recurrence rate（4/39） and 10.3%（6/21） 28.5% difference between two groups was statistically significant（P〈0.05）.Conclusion：Astragalus and baicalin joint esomeprazole effectively eradicate resistant Hp,Hp related peptic ulcer increased resistance to the clinical efficacy and reduce the Hp recurrence rate.