辛伐他汀对脑出血的治疗作用及白细胞介素-1β表达的影响

目的观察脑出血患者用辛伐他汀治疗效果及白细胞介素-1β（IL-1β）的变化情况。方法选择住院脑出血患者120例随机分为治疗组（60例）和对照组（60例）。治疗组从入院起给予口服或鼻饲辛伐他汀（杭州默沙东制药有限公司）10mg，1次／晚。所有患者均于入院后第24h、7天、14天、24天应用双抗体夹心ELISA法检测血清IL-1β。使用欧洲卒中量表（ESS）评定神经功能缺损的程度，评定治疗前后的日常生活能力（AD）评分采用Batherel指数量表）。结果两组24h血清IL-1β含量均为最高，第7天开始下降（P〈0．05），治疗组各期IL-1β均低于对照组（P〈0．05）。所有数据以（x±s）表示，全部数据采用SPSS11．0软件包进行统计学处理，两组间比较用t检验，P〈0．05为差异有统计学意义。结论血清IL-1β参与了脑出血急性期的炎性病理过程，辛伐他汀可使血中IL-1β含量降低，减轻炎性反应，促进脑功能恢复。

Objective To obersve the effects of simvastatin on the cerebral hemorrhage and its effects on interleukin - 1 β （ IL - 1β） level. Methods 120 hospitalized cases of cerebral hemorrhage were randomly devided into treating group and control group, with 60 patients each. Simvastatin was administered by nasogastric or oral feeding from the first day of addmission, 10mg per night. IL - 1 β was tested in all the patients on 24 hours, 1 d, 7d, 14d and 24d with ELISA after admission. The stroke scale of Europe was applied to evaluate the damage of nerve function, activity of daily living （ AD ） pre and post treatment was evaluated with Batherel index table. Results IL - 1 βwas highest on 24 hours in both goups, and began to drop from the 7th day （ P 〈 0.05 ）, IL - 1βwas lower in the treatment group at all stages than in the control group（P 〈0. 05）. All the data were presented with （x^-±s）, SPSS 11. 0 was applied for statistics, t test for comparison between two groups, P 〈 0. 05 is taken as the statistically different. Conclusions Serum IL - 1βwas related to the pathological process of inflammation of cerebral hemorrhage at acute stage. Simvastatin can lower the level of IL - 1 β thus reduce the inflammation reaction and help for the recovery of brain function.