尼古丁对药物性胃溃疡影响的实验研究

Effect of Nicotine on Drug-induced Gastric Ulcer

目的探讨尼古丁对小鼠药物性胃溃疡的影响。方法随机将昆明种小鼠分为5组:生理盐水对照组及0.25,0.5,1.0,10 mg/kg尼古丁实验组。消炎痛灌胃制成小鼠胃溃疡模型,造模前和造模后用尼古丁灌胃,计算溃疡指数。结果尼古丁组胃溃疡指数明显低于生理盐水对照组。结论在一定剂量范围内,尼古丁能预防药物性胃溃疡生成,治愈和恢复消炎痛诱发的胃黏膜损伤。

Objective To explore the effect of nicotine on drug-induced gastric ulcer in mice. Methods Kunming mice were randomly divided into five groups of saline control group and 0.25, 0.5, 1.0, 10 mg/kg nicotine groups. The gastric ulcer model in mice was induced by intragastric administration of indomethacin, and the mice were intragastrically administered with nicotine before or after the establishment of gastric ulcer model. The ulceration index was measured. Results Compared with the control group, the ulceration indexes in nicotine groups were all obviously decreased. Conclusion Within a certain dose range, nicotine can prevent from the formation of drug-induced gastric ulcer and promote the healing and recovery of gastric mucosal injury caused by indomethacin.