妊娠期外阴阴道假丝酵母菌病治疗方案分析

Evaluation of therapeutic regimens of vulvovaginal candidiasis during pregnancy period

目的评价妊娠期外阴阴道假丝酵母菌病3种常用治疗方案的疗效,找到临床最佳治疗方案。方法将患有外阴阴道假丝酵母菌的孕妇213例,随机分为对照组(66例)、低剂量组(74例)和高剂量组(73例),分别予以克霉唑连续7 d、凯妮汀2、3次,治疗1周后复查确定治疗效果。结果 3组的真菌治愈率分别为89.4%、91.9%、95.9%;有效率为95.5%、97.3%、97.3%,差异无统计学意义。结论 3组治疗方案均安全有效,疗效并无显著不同,低剂量组拥有更短的疗程和更少的用药次数,经济便捷,更值得推广。

OBJECTIVE To evaluate the curative effect of three therapeutic regimens of vulvovaginal candidiasis,and find the best regimen.METHODS A total of 213 pregnant women with vulvovaginal candidiasis were put into three groups,66 cases in control group were taken clotrimazole for 7days,74 cases in low-dose group were taken canesten for twice,and 73 cases in high-dose group were taken canesten for thrice.Then the treatment effect after 1 week was checked.RESULTS The cure rates of fungi in the three groups were 89.4%,91.9% and 95.9%,respectively,while the effective rates were 95.5%,97.3% and 97.3%,respectively.But there were no significant difference in the three groups.CONCLUSION All the three therapeutic regimens are safe and effective with no significant difference.But the low-dose group has shorter time of therapy and less number of medication,which make it more economic and convenient than other groups.