医院革兰阳性球菌的耐药性分析

Drug resistance of gram-positive coccus in hospitals

目的分析山西省眼科医院临床分离的革兰阳性球菌感染情况和耐药特征,为临床用药提供依据。方法收集医院2009年5月-2010年6月医院患者眼部标本分离培养、药物敏感试验。结果在177株感染阳性菌中,表皮葡萄球菌最多,耐甲氧西林表皮葡萄球菌为70.37%;对常用抗菌药耐药率很高,替考拉宁、万古霉素、利奈唑胺对葡萄球菌属、肠球菌属、链球菌属仍具有很好的抗菌活性。结论应加强医院感染控制,防止耐药菌株的产生。

OBJECTIVE To approach the drug resistance status of clinically isolated Gram-positive cocci in Shanxi Eye Hospital and provide the evidence for clinically reasonable use of antibiotics.METHODS A total of 177 strains of Gram-positive cocci were isolated from all kinds of eye specimens from May 2009 to Jun 2010 Organisms were cultivated and identified according to National Clinical Laboratory Operation Rule.The drug sensitivity testing was performed by MIC methods.RESULTS Among the 177 strains,the isolating rate of Staphylococcus epidermidis ranked the first.The detection rate of meticillin-resistant S.epidermidis（MRSE） was 70.37%.The Gram-positive cocci were resistant to the commonly used antibiotics in different degrees except for 100% sensitive to vancomycin,teicoplanin,linezolid and quinupristin/alfopristin.CONCLUSION The management of nosocomial infections should be strengthened to prevent the dissemination and epidemic of the drug resistant strains.