128株流感嗜血菌对抗菌药物耐药性分析

Drug resistance of 128 strains of haemophilus influenzae to antibiotics

目的对襄樊市中医院2008-2009年临床微生物室分离出的流感嗜血菌耐药性及耐药趋势进行回顾性分析,为指导临床合理用药提供科学依据;同时优化检测方法,提高检出率。方法对128株流感嗜血菌进行β-内酰胺酶测定,采用K-B法进行体外药敏试验。结果 128例流感嗜血菌中,产β-内酰胺酶率为28.69%,对氨苄西林、氨苄西林/舒巴坦、头孢噻肟、磺胺甲噁唑/甲氧苄啶、头孢呋辛、环丙沙星、阿奇霉素、左氧氟沙星、氯霉素、亚胺培南的耐药率分别为47.66%、15.63%、28.91%、56.25%、27.34%、19.53%、19.53%、29.69%、46.09%、0。结论流感嗜血菌对亚胺培南、氨苄西林/舒巴坦、环丙沙星、阿奇霉素的敏感性较高,临床医师可选择这些药物进行治疗。

OBJECTIVE To retrospectively analyze the drug resistance trend and drug resistance of Haemophiius influenzae isolated from clinical microorganism room in the Xiangfan Traditional Chinese Medicine Hospital in the whole year of 2009,to provide scientific data for the clinical on rational drug use and optimize the detection method and improve the detection rate.METHODS The determination of β-lactamase was performed on 128 strains of HI and drug sensitivity was tested in vitro by using the method of Kirty-Bauer.RESULTS In 128 strains of H.influenzae,the β-lactamase producing rate was 28.69%,the drug resistant rates to ampicillin,ampicillin sulbactam,cefotaxime,cotrimoxazole,cefuroxime,ciprofloxacin,azithromycin,levofloxacin,chloramphenicol and imipenem were 47.66%,15.63%,28.91%,56.25%,27.34%,19.53%,19.53%,29.69%,46.09% and 0,respectively.CONCLUSION H.influenzae is sensitive to imipenem,ampicillin/sulbactam,ciprofloxacin and azithromycin,the clinicians can choose these drugs for the treatment.