结核抗体检测在住院患者结核病诊断中的临床意义

Clinical value of tuberculosis antibody assays in diagnosis of inpatients with tuberculosis

目的探讨结核抗体检测在住院患者结核病诊断中的临床价值。方法对医院1911例住院患者,应用3种方法同时检测血清结核抗体的结果进行回顾性分析。结果 3种方法联合检测结核抗体的敏感性为79.8%,特异性为81.9%,结果优于单一检测,均P=0.000;与传统方法相比,3种方法联合检测结核抗体的阳性率为77.6%,优于抗酸染色法(33.6%,P=0.000),略高于结核菌素试验法(66.4%),差异无统计学意义。结论 3种方法联合检测结核抗体,敏感性高,操作简单、快捷,成本低,对住院患者结核病辅助诊断有重要的临床应用价值。

OBJECTIVE To investigate the clinical value of the tuberculosis antibody assays in the diagnosis of In-Patients with tuberculosis.METHODS The results of serum Mycobacterium tuberculosis antibody（TB-Ab） tests of 1911 inpatients were retrospectively analyzed.RESULTS The sensitivity and specificity of combined measurement of immunochromatographic method,dot-immunogold filtration assay（DTBA） and immunoblotting method were 79.8% and 81.9%,respectively.They were obviously higher than that of single detection.TB-Ab assay,P=0.000.Compared with traditional methods,the positive rate of the combined measurement of three methods（77.6%） was significantly higher than sputum acid-fast bacillus（AFB） smear method（33.6%,P=0.000）,and higher than PPD test（66.4%）,while there was no statistical difference,P=0.068.CONCLUSION With high sensitivity,simple operation and low cost,the combined measurement of 3 TB-Ab assays helps to make an accurate clinical diagnosis of tuberculosis.