一类噁唑啉类化合物的合成及红外光谱分析

Synthesis and IR Spectroanalysis of Oxadiazolines Compounds

以3-碘苯甲酸为原料,在浓硫酸作用下,与乙醇反应制得3-碘苯甲酸乙酯(1),再与80%的水合肼反应制得3-碘苯甲酰肼(2)。然后将化合物(2)分别与4-甲基苯甲醛、2-氯苯甲醛、4-氯苯甲醛、4-羟基苯甲醛、2,4-二氯苯甲醛、4-甲氧基苯甲醛、3-硝基苯甲醛、4-硝基苯甲醛、4-二甲氨基苯甲醛反应得到相应的酰腙(3a—3i)。最后(3a—3i)分别与丙酸酐脱水环化成了3-N-丙酰基-2-芳基-5-(3-碘苯基)-1,3,4-噁唑啉类化合物(4a—4i),通过红外光谱对该类化合物进行光谱分析。

Ethyl 3-iodobenzoate（1） was prepared by reaction of 3-iodobenzoic acid with anhydrous ethanol in sulfuric acid.Then this compound reacted with 80% hydrazine hydrate to get 3-iodobenzoylhydrazine（2）.And then the reaction of compound（2） with 4-methylbenzaldehyde,2-chlorobenzaldehyde,4-chlorobenzaldehyde,4-hydroxybenzaldehyde,2,4-dichlorobenzaldehyde,4-methoxybenzaldehyde 3-nitrobenzaldehyde,4-nitrobenzaldehyde and dimethylaminobenzaldehyde respectively produced corresponding hydrazones（3a—3i）.Then 3a—3i respectively cyclodehydrated with propanoic anhydride to afford 3-N-propanoyl-2-aryl-5-（3-iodophenyl）-1,3,4-oxadiazolines（4a—4i）,structures of 4a—4i were confirmed by IR spectroscopy.