脑出血后抑郁症状与甲状腺功能相关研究

Investigation of the relationship between thyroid function and depression occurred with cerebral hemorrhage

目的研究脑出血患者急性期抑郁症状与甲状腺功能的关系。方法选择首次发病的急性脑出血患者100例,根据抑郁自评量表(SDS)和汉密尔顿抑郁量表(HAMD)评分结果分为伴抑郁组和无抑郁组,分析2组患者血清三碘甲状腺原氨酸(T3)、甲状腺素(T4)、游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)、抗甲状腺过氧化物酶抗体(TPO-Ab)和抗甲状腺球蛋白抗体(TG-Ab)水平。结果伴抑郁组患者血清FT3和TSH水平显著低于无抑郁组,FT4显著高于无抑郁组(P<0.01);血清T3、T4、TPO-Ab、TG-Ab水平伴抑郁组与无抑郁组之间差异无统计学意义(P>0.05)。结论急性脑出血患者抑郁症状可能与甲状腺功能变化有关,血清FT3、FT4和TSH可作为评价急性脑出血患者抑郁症状的客观指标。

Objective To investigate the relationship between depression and thyroid function in patients with acute cerebral hemorrhage.Methods 100 patients with primary cerebral hemorrhage were enrolled and classified into 2 groups（depression group and non-depression group） according to depression self rating scales（SDS） and Hamilton depression rating scale（HAMD）.Triothyrone（T3）,thyroxine（T4）,free triothyrone（FT3）,free thyroxine（FT4）,thyrotropic-stimulating hormone（TSH）,anti thyroid peroxidase antibody（TPO-Ab） and anti thyroglobulin antibody（TG-Ab） in serum were determined respectively.Results The levels of serum FT3 and TSH were lower,and FT4 was higher in depression group than in non-depression group（P〈0.01）.There was no significant difference between depression group and non-depression group in the levels of T3,T4,TPO-Ab and TG-Ab（P〈0.05）.Conclusions Depression symptoms occurred in the patients with acute cerebral hemorrhage are related with the changes of thyroid function.The levels of FT3,FT4 and TSH in serum may be the markers of depression in patients with acute cerebral hemorrhage.