急性心肌梗死超早期溶栓分析

Analysis of ultra-early thrombolytic therapy in acute myocardial infarction

目的:探讨急性心肌梗死超早期溶栓的作用。方法:邹城市红十字会急救中心2005年1月～2009年2月行溶栓治疗ST段抬高型急性心肌梗死116例,随机分为超早期(≤3 h)溶栓组56例,非超早期(3～12 h)溶栓组60例,以间接指标判断其溶栓成功率,并对比急性心肌梗死患者1年后再发心肌梗死、心力衰竭、致命性心律失常、猝死等严重心血管事件的发生率。结果:超早期溶栓组溶栓成功率明显高于非超早期溶栓组,分别为82%、43%;而1年后严重心血管事件的发生率明显降低,组间差异有统计学意义(P<0.01)。结论:超早期溶栓大大提高了AMI的再通率,挽救了心肌。

Objective： To investigate the role of ultra-early thrombolytic therapy in acute myocardial infarction （AMI）. Methods： 116 patients with acute ST-segment elevation AMI in the Red Cross Emergency Center of Zoucheng City from January 2005 to February 2009 were randomly divided into ultra-early （≤3 h） thrombolysis （56 cases） and non-ultra-early （3-12 h） thrombolytie group （60 cases）, indirect indicators were used to judge the success rate of thrombolysis, and compared the incidence one year after AM/ recurring myocardial infarction, heart failure, fatal arrhythmia, sudden death and other serious cardiovascular events. Results： The success rate of thrombolysis in ultra-early thrombolytic group was significantly higher than that of the non-ultra-early thrombolytic group （82%, 43%）, and one year after the occurrence of serious cardiovascular events was significantly lower than that of the non-ultra-early thrombolytic group （P〈0.01）. Conclusion： Ultra-early thrombolytic recanalization greatly increases the recanalization rate of AMI, and saves the cardiac muscle.