2948株2009年临床分离致病菌的耐药性分析

Drug resistance analysis of 2,948 clinic isolates in 2009

目的分析2948株2009年临床分离致病菌的种类及其耐药性。方法用VITEK分析仪进行细菌鉴定及药敏分析。结果与2004年比,2009年临床分离菌的总数倍增,革兰阴性菌占75%,上升7%。常见菌的种类一致,但鲍曼不动杆菌(AB)的分离率为15%,增高了8%。痰及尿中的分离率高于2004年,为44%和26%。呼吸内科(11%)和ICU(9%)仍为主要来源。常见菌,特别是MRSA,HLAR屎肠球菌及AB的耐药率显著升高。万古霉素和亚胺培南分别为治疗革兰阳性和革兰阴性菌感染的首选药,但非发酵菌属耐亚胺培南率升高。结论细菌的耐药性日趋严重,应加强药敏监测,促进抗生素的合理应用,以降低发病率和病死率。

Objective To analyze the species and drug resistance of 2,948 clinic isolates in 2009. Methods Bacteria and their drug susceptibility were identified by VITEK analytic instrument. Results Compared with 2004, the total number of clinical isolates was doubled in 2009, and Gram-negative bacteria accounted for 75%, increased 7%. The species of common isolates were unanimous, except AB which accounted for 15%, increased 8%. Samples isolated from sputum and urine were higher than those isolated in 2004, accounted for 44% and 26% respectively. Department of respiratory unit （11%） and ICU （9%） remained the main source. The drug resistance rates of common bacteria, especially MRSA, HLAR Enterococcus faecium, and AB were increased significantly. Vancomycin and imipenem were preferred drugs for the treatment of Gram-positive and Gram-negative bacteria infections respectively, but the resistance rates of non-fermentative genus to imipenem were increased. Conclusion With the increase in bacterial resistance to antibiotics, we should strengthen the monitoring of drug sensitivity and promote the reasonably use of antibiotics to decrease the morbidity and fatality.