男性迟发性性腺功能减退症的发病机制与流行病学

The Mechanism and Epidemiological Research on Late-onset Hypogonadism in Males

中老年男性迟发性性腺功能减退症(late-onsethypogonadism,LOH)的发病机制是多种机制损害雄激素的正常分泌和生物活性,包括雄激素水平下降和雄激素受体异常,是原发性和继发性因素共同作用的结果。综述LOH的发病机制、发病率及危险因素,后者包括疾病和药物的影响、过度肥胖、不良生活方式、环境与遗传因素的影响、精神心理因素、社会经济因素和文化教育水平。

With the rapid aging progression for the human being,more concern was focused on the research of late-onset hypogonadism（LOH）.In the review article,the mechanism and epidemiological research on LOH is sumarized.The mechanism of LOH is the combinated effects of primary and secondary factors,which achieved by many pathways to damage the secretion and bio-activity of androgen including the androgen level and androgen receptor（AR）.Morbidity,susceptibility and risk factors are reviewed including diseases and medication,obesity,untoward life style,environmental and genetic factors,psychological factor,social-economic factors and cultural level.