摘要
目的探讨二甲双胍对多囊卵巢综合征(PCOS)合并胰岛素抵抗(IR)患者内分泌的影响。方法 P-COS合并IR患者50例于自然月经或撤退性出血第2天开始服用二甲双胍12周,观察治疗前后血清促卵泡生成素(FSH)、黄体生成素(LH)、睾酮、雌二醇、雄烯二酮、性激素结合蛋白(SHBG)浓度、胰岛素(INS)水平以及血糖的变化。结果治疗后患者各时相INS水平显著下降,差异有统计学意义(P<0.01);患者血清LH、LH/FSH比值、睾酮和雄烯二酮水平均显著下降,差异有统计学意义(P<0.01);SHBG水平显著升高,差异也有统计学意义(P<0.01)。结论二甲双胍通过改善IR降低INS水平,改善患者临床症状和内分泌指标,使PCOS患者异常的血激素相得到明显改善。
Objective To evaluate the effect of metformin on the endocrine function on the patients with polycystic ovary syndrome（PCOS） complicating with insulin resistance.Methods 50 patients with polycystic ovary syndrome complicating with insulin resistance began to taking metformin on 2 d of the natural menstruation or withdrawal bleeding for 12 weeks.Before and after treatment,serum luteinizing hormone（LH）,follicle-stimulating hormone（FSH）,estradiol（E2）,testosterone（T）,androstenedione（A）,sex hormone binding globulin（SHBG）,insulin and glucose concentrations were determined.Results After treatment,serum insulin levels were decreased significantly with statistical difference（P0.01）.The serum LH,T,A concentrations and the ratio LH/FSH were decreased,showing statistical difference（P0.01）.The SHBG levels were increased significantly with statistical difference（P0.01）.Conclusion Metformin could improve abnormal insulinemia obviously by improving insulin resistance,reducing insulin level,improving clinical symptoms and endocrine indexes in the patients with PCOS.
出处
《检验医学与临床》
CAS
2011年第2期135-136,139,共3页
Laboratory Medicine and Clinic
