钙及维生素D_3治疗中老年女性骨质疏松症的临床研究

Clinical research of calcium and vitamin D_3 on treating osteoporosis in middle-aged and old women

目的观察钙及活性维生素D3(VitD3)在治疗中老年女性骨质疏松症中的疗效。方法 300例中老年女性骨质疏松症患者随机分成钙和VitD3组与钙剂组,治疗2年,钙加VitD3组采用钙尔奇D联合骨化三醇治疗,钙剂组采用钙尔奇D治疗。结果两组生活能力明显提高,双手握力增加(P<0.01)。钙剂组患者经过治疗后腰椎、股骨大转子骨密度增加(P<0.01),股骨颈骨密度降低;钙加VitD3组全部骨密度降低。结论钙及VitD3在治疗中老年女性骨质疏松症中对改善临床症状疗效良好。

Objective To inquire into the clinical effects of calcium and activated vitamin D3 on treating osteoporosis in middle-aged and old women.Methods 300 patients were randomly divided into two groups：calcium group（Ca） treated with calcium for 24 months and calcium combined vitamin D3 group（Ca ＋ VitD3） treated calcium and activated vitamin D3 for same duration.Results The abilities of living of two groups were greatly improved and with the grip strength of two hands was increased.The bone mineral density of lumbar and greater trochanter of femur was increased,but the bone mineral density of collum femoris was decreased in Ca group,the bone mineral density all was decreased in Ca ＋ VitD3 group.Conclusion Clinical effects of calcium and vitamin D3 on treating osteoporosis in middle-aged and old women are very good.