期刊文献+

阿尔茨海默病的致病因素和临床用药研究 被引量:9

下载PDF
导出
摘要 阿尔茨海默病(AD)亦称老年性痴呆症,是一种常见的中枢神经系统退行性疾病,在65岁以上老年人中患病率可高达5%~10%。据估计,全世界目前有2 430万人患有老年痴呆。随着当今世界人口老龄化,AD发病率日趋增高,其患者多有记忆力、定向力及社会活动障碍,必将带来更大的社会问题和经济问题。因此,把现阶段对AD致病机制及临床用药的研究成果进行综合分析和概述,将对今后AD的防治有意义。
出处 《检验医学与临床》 CAS 2011年第2期251-252,共2页 Laboratory Medicine and Clinic
  • 相关文献

参考文献7

二级参考文献31

  • 1陈新平,陈彪.阿尔茨海默病病因学及发病机制研究进展[J].中国现代神经疾病杂志,2005,5(3):152-155. 被引量:27
  • 2[1]Pratico D,Uryu K,Leight S,et al.Increased lipid peroxodation precedes amyloid plaque formation in an animal model of Alzheimer amyloidosis[J].Journal of Neuroseienee,2001,21:4183~4187.
  • 3[2]John H,Dennis JS.The amyloid hypothesis of alzhemier's disease progress and problems on the road to therapeutics[J].Science,2002,297:353~359.
  • 4[3]James CV,Tracey CD,Dickson PA,et al.The cause of neurinal degeneration in Alzheimer's Disease[J].Progress in Neurobiology,2000,60:139~165.
  • 5[4]Roberson ED,Mucke L.100 years and counting:prospects for defeating Alzheimer's disease[J].Science,2006,214:781~784.
  • 6[5]Dorgert M,Spihanrint AG.A century of Alzheimer's isease[J].Science,2006,314:777~780.
  • 7[6]Morihara T,Teter B,Yang FS,et al.Ibuprofen suppresses interleukin-1 induction of proamyloidogenic-α1 antichymotrypsin to ameliorate-β amuloid pathology in Alzheimer's models[J].Neuropsychophannaeology,2005,30:1111~1120.
  • 8[8]Jessica Berman.Researchers on verge of blood test for Alzheimer's diseases[J].Nature Medicine,2007,14.
  • 9Lotz M,Ebert S,Esselmann H,et al.Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures[J].Neurochem Stry,2005,94 (2):289-298.
  • 10Sondag CM,Combs CK.Amyloid precursor protein cross-linking stimulates β-amyloid production and pro-inflammatory cytokine release in monocytic lineage cells[J].Neurochem Stry,2006,97 (2):449-461.

共引文献55

同被引文献146

引证文献9

二级引证文献48

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部