乌司他丁对腹腔镜直肠肿瘤切除术患者肝肾功能的影响

目的观察乌司他丁对腹腔镜直肠肿瘤切除术患者肝、肾功能的影响。方法选择60例在气管内全麻下行腹腔镜直肠肿瘤切除术的患者,随机分为乌司他丁治疗组(U组,n=30)和对照组(C组,n=30),乌司他丁治疗组在术前、术中及术后第1～3天给予乌司他丁20万U+100mL生理盐水静脉滴注;对照组给予等量生理盐水静脉滴注。两组患者分别于术前、术后第l、3、5天抽取外周静脉血检验肝、肾功能,包括谷丙转氨酶(ALT)谷草转氨酶(AST)血肌酐(Scr)尿素氮(BUN)。结果两组患者术后第1、3天血ALT、AST、BUN、Scr均较术前明显升高(P<0.05),但乌司他丁治疗组升高程度明显低于对照组(P<0.05);术后第5天两组患者血ALT、AST、BUN、Scr均恢复至术前水平(P>0.05)。结论乌司他丁对腹腔镜直肠肿瘤切除术患者围手术期肝肾功能有确实的保护作用。

Objective To observe the ulinastatins＇ protective effects on liver and renal function of the patients undergoing laparoscopic surgery for rectal carcinoma.Methods Sixty ASA I patients undergoing laparoscopic surgery for rectal carcinoma were randomly divided into two groups：group U received ulinastatin（2×105IU）on 1st preoperative day during surgery and 1st 2nd and 3rd postoperative day And group C only accepted normal saline.The liver and renal function pre-and post-operation were determined and compared in the two groups Results Serum ALT and AST levels in treatment group were significantly lower than those in control group 72 hours post-operation and scrum BUN and Scr levels in treatment group were significantly lower than those in control group 72 hours post-operation（P0.05）.Conclusion Ulinastatin can play certain role in protecting the liver and renal function of the patients undergoing laparoscopic surgery for rectal carcinoma.