尖海龙对胚胎尿生殖窦致小鼠前列腺增生模型的药理作用

Pharmacological researches of Syngnathus acus Linnaeus on mouse benign prostatic hyperplasia model induced by fetal urogenital sinus implants

目的研究尖海龙对尿生殖窦致小鼠前列腺增生(benign prostatic hyperplasia,BPH)模型的药理作用,探讨尖海龙应用于治疗良性前列腺增生海洋药物开发的可行性。方法建立16d龄胎鼠尿生殖窦组织植入法诱导小鼠BPH模型,连续灌胃给予尖海龙(50,100,200mg.kg-1)30d后,评价对BPH小鼠前列腺指数和精囊腺指数、血清酸性磷酸酶(ACP)、前列腺组织形态参数的影响。结果与模型组相比,尖海龙具有升高精囊腺指数,降低前列腺指数、血清ACP、腺体周长、腺体面积、腺上皮高度的作用。结论尖海龙具有治疗BPH的作用,同时补肾壮阳,克服治疗前列腺增生药物阳痿少精等副作用,可开发成为治疗BPH的海洋药物。

Objective To study the effects of Syngnathus acus Linnaeus on mouse benign prostatic hyperplasia（BPH） induced by fetal urogenital sinus implants,and to investigate the possibility of applying Syngnathus acus Linnaeus to BPH treatment.Methods Mouse BPH model was established by implanting 16 days old embryo urogenital sinus of mouse.After oral administration of Syngnathus acus Linnaeus（50,100,200 mg.kg-1） for 30 days,the indices of seminal vesicle and prostatic weight,serum acid phosphatase（ACP）,prostatic gland perimeter,gland area and gland epithelial height of mice were measured.Results Compared to BPH model group,oral administration of Syngnathus acus Linnaeus reduced the prostatic weight,serum ACP,prostatic gland perimeter,gland area and gland epithelial height,and increased the index of seminal vesicle.Conclusion As a traditional drug for invigorating the kidney and strengthening Yang,increasing number of sperms,Syngnathus acus Linnaeus showed therapeutic effects on BPH,hence could be developed a marine drug for treatment of BPH without side effects such as impotence and oligospermatism.