川崎病诊治进展

Progress of Diagnosis and Treatment of Kawasaki Disease

川崎病的病因及发病机制至今未明。其病因可能与感染、遗传易感及超免疫反应有关,发病机制与免疫反应、细胞因子及炎性介质、血管内皮功能紊乱、血小板活化、易感基因多态性等有关。联合应用丙种球蛋白和阿司匹林是川崎病的首选治疗方案。对于糖皮质激素的使用临床尚有争议,严重冠状动脉病变可采用外科及介入治疗。

The etiology and pathogenesis of Kawasaki disease remains unknown.The etiology may be correlated to infection,genetic susceptibility and super-immune response,pathogenesis relates to immune response,cytokines and inflammatory mediators,vascular endothelial dysfunction,platelet activation,susceptibility genes polymorphism and so on.Treatment with intravenous immune globulin and aspirin remains the primary management strategy and steroid therapy remains controversial.In severe circumstances,coronary artery surgery or inter ventional means in children with Kawasaki disease has been required,albeit infrequently.