单麻叶千里光中肝毒吡咯里西啶生物碱的分离与鉴定

Pyrrolizidine alkaloids of Senecio cannabifolius var. integrilifolius

目的:研究菊科千里光属植物单麻叶千里光Senecio cannabifoliusvar.integrilifolius的肝毒性吡咯里西啶生物碱。方法:运用多种色谱方法进行分离纯化,应用现代波谱学分析方法进行结构鉴定。结果:从单麻叶千里光的总碱部位中分离得到4个吡咯里西啶生物碱,分别鉴定为:jacobine(1),jacoline(2),jaconine(3),senecicannabine(4)。结论:化合物1～4均为首次从该植物中分离得到。

Objective： To study the pyrrolizidine alkaloids of Senecio cannabifolius var. integrilifolius. Method： Various chromatographic methods were used for the isolation and purification of chemical constitutents of the plant and their structures were elucidated on the basis of spectral analysis. Result： Four compounds were determinated as jacobine（ 1 ） ,jacoline（2）, jaconine（3）, senecicannabine（4）. Conclusion： All compounds were isolated from this plant for the first time.