聚丙交酯-乙交酯共混膜与梯度膜的体外降解特性研究

Investigation of ln-vitro degradation properties of poly(lactide-co-glycolide) blended and gradient films

以聚丙交酯-乙交酯(PLGA)50/50与75/25为原料,采用流延法制成薄膜,其中包括PLGA50/50单成分膜、PLGA75/25单成分膜、两者的共混膜以及成分非均匀分布的梯度膜,将4种不同类型的膜浸泡在37℃、pH=7.4的磷酸盐缓冲液中进行体外降解实验。对4种膜降解过程中的分子量、质量损失、吸水率、pH值以及表面形貌等性能进行分析。结果表明,PLGA梯度膜具有最平稳的降解特性。

Poly（lactide-co-glycolide）（PLGA） 50/50 and 75/25 were applied as materials,and films were prepared by casting method.The PLGA films included PLGA 50/50 single-component films,PLGA 75/25 single-component films,blended films of two kind of PLGAs,and gradient films with non-uniform component distribution.The four types of PLGA films were immersed in pH7.4 phosphate buffered saline at 37℃.The properties of these PLGA films such as molecular weight,mass loss,water absorption,pH value,and morphology were analyzed during degradation process.The results showed that the PLGA gradient films had the stablest degradation properties.