羧基化氧化石墨烯-镧复合物抗凝血性能的研究

A study of anticoagulant properties on carboxylated graphene oxide-La composite

将稀土La3+离子接枝到羧基化的氧化石墨烯片层上,制备了一种功能化的氧化石墨烯(GeneO-La)。利用红外光谱和透射电镜等手段对所合成的GeneO-La复合物进行了表征;将功能化的氧化石墨烯应用到抗凝血体系中,研究其抗凝血性能。结果表明,La3+已经通过配位作用吸附在羧基化的氧化石墨烯片层上。通过溶血实验和血浆复钙时间实验可以看出随着复合物浓度的增加,复钙时间逐渐缩短,同时复合物的溶血率在浓度低时都<5%,符合稀土元素的Hormesis效应,即GeneO-La复合物在低浓度时表现出优良的抗凝血性能。

In this paper,a functional graphene oxide was prepared with La3＋ ions and the carboxylated graphene oxide sheet.The structure and properties of GeneO-La composite was characterized by Fourier transformed infrared specttroscopy（FT-IR） and trans mission electron microscopy（TEM）;the functional graphene oxide was added to anticoagulation system and its effects on anticoagulant properties were studied.Results show that the La3＋ ions have been coordinated on graphene oxide sheet layer.The blood compatibility of the GeneO-La composite was evaluated by plasma recalcification time test and hemolysis test.It was observed that the plasma recalcification time gradually shortened with the increase in the concentration of composite,and hemolysis rate were less than 5% in lower concentrations,it conformed to the hormesis effect of rare earth elements.Therefore,the GeneO-La composite is a new carboxylated graphene oxide composite,which has anticoagulant effect when it has lower concentrations.