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围产期PTHrP的生理作用及意义 被引量:3

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摘要 机体中甲状旁腺激素相关肽( T P Hr P)具有多种生理调节作用,不仅具有甲状旁腺激素( P T H)样的生理作用,还参与细胞的分化与增殖,中枢神经系统、骨、软骨系统的发育,平滑肌系统的舒张以及生殖系统的调控,尤其在妊娠期、产褥期与胎儿生长发育、器官成熟、分娩发动等机理有关,在围产期发挥着重要作用。
作者 金镇 赵怡璇
出处 《国外医学(妇幼保健分册)》 1999年第3期97-99,共3页 Foreign Medical Sciences (Section of Maternal and Child Health)
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参考文献1

  • 1市 清健 铃木真 等.-[J].日产妇志,1998,50:148-148.

同被引文献61

  • 1Moseley JM,Kubota M,Diefenbach-Jagger H,Wettenhall RE,Kemp BE,Suva L J,Rodda CP,Ebeling PR,Hudson P J,Zajac JD.Parathyroid hormone-related protein purified from a human lung cancer cell line.Proc Natl Acad Sci USA,1987,84(14):5048-5052.
  • 2Suva LJ,Winslow GA,Wettenhall RE,Hammonds RG,Moseley JM,Diefenbach-Jagger H,Rodda CP,Kemp BE,Rodrigue H,Chen EY.A parathyroid hormone-related protein implicated in malignant hypercalcemia:cloning and expression.Science,1987,237(4817):893-896.
  • 3Moniz C,Burton PBJ,Malik AN,Dixit M,Banga JP,Nicolaides K,Quirke P,Knight DE,McGregor AM.Parathyroid hormone-related peptide in normal human fetal development.J Mol Endocrinol,1990,5(3):259-266.
  • 4Escande B,Lindner V,Massfelder T,Helwig J J,Simeoni U.Developmental aspects of parathyroid hormone-related protein biology.Semin Perinatol,2001,25(2):76-84.
  • 5Philbrick WM,Wysolmerski JJ,Galbraith S,Holt E,Orloff J J,Yang KH,Vasavada RC,Weir EC,Broadus AE,Stewart AF.Defining the roles of parathyroid hormone-related protein in normal physiology.Physiol Rev,1996,76(1):127-173.
  • 6Pinheiro PL,Cardoso JC,Gomes AS,Fuentes J,Power DM,Canário AV.Gene structure,transcripts and calciotropic effects of the PTH family of peptides in Xenopus and chicken.BMC Evol Biol,2010,10:373.
  • 7Luparello C,Burtis WJ,Raue F,Birch MA,Gallagher JA.Parathyroid hormone-related peptide and 8701-BC breast cancer cell growth and invasion in vitro:evidence for growth-inhibiting and invasion-promoting effects.Mol Cell Endocrinol,1995,111(2):225-232.
  • 8LuparelloC,Sirchia R,Pupello D.PTHrP(67-86) regulates the expression of stress proteins in breast cancer cells inducing modifications in urokinase-plasminogen activator and MMP-1 expression.J Cell Sci,2003,116(12):2421-2430.
  • 9Lam MHC,Briggs L J,Hu W,Martin T J,Gillespie MT,Jans DA.Importin β recognizes parathyroid hormone-related protein with high affinity and mediates its nuclear import in the absence of importin α.J Biol Chem,1999,274(11):7391-7398.
  • 10Lam MH,Hu W,Xiao CY,Gillespie MT,Jans DA.Molecular dissection of the importin betal-recognized nuclear targeting signal of parathyroid hormone-related protein.Biochem Biophys Res Commun,2001,282(2):629-634.

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