甘露低聚糖磁性微球制备工艺研究

Preparation of mannan-oligosaccharides magnetic microspheres

以甘露低聚糖(MOS)和Fe3O4为原料制备甘露低聚糖磁性微球。以磁性微球的平均粒径和磁响应性为考察指标,通过单因素实验,考察了甘露低聚糖量、交联时间、交联温度和环氧氯丙烷(ECH)的量对产物的影响,运用红外光谱(IR)和扫描电镜(SEM)对产物进行了表征。最后通过正交实验确定最佳工艺条件为:甘露低聚糖浓度为0.01g/mL,交联时间为60min,交联温度为60℃,环氧氯丙烷的用量为8mL。

The mannan-oligosaccharides magnetic microspheres were prepared with MOS and Fe3O4.Using average particle size and magnetic responsiveness as indicators,the effect of different factors on preparation of mannan-oligosaccharides magnetic microspheres were researched by single-factors tests,the complex was detected by IR and SEM to check its symbol.The synthetic conditions of mannan-oligosaccharides magnetic microspheres were optimized through orthogonal test and the optimum experimental conditions are as follows： concentration of MOS was 0.01 g/mL,reaction time was 60 min,cross-linking temperature was 60 ℃ and the volume of ECH was 8 mL.