某高校医院药品不良反应报告分析

Analysis of Adverse Drug Reactions Reported in a University Hospital

目的:了解高校医院药品不良反应发生的特点及一般规律,促进临床合理用药。方法:汇总统计2008-2009年上报的83例药品不良反应(ADR),分别从患者性别、年龄、给药途径、药品种类、累及器官或系统及临床表现等进行统计分析。结果:83例ADR报告中男女发生率相当;主要给药途径为口服(51.8%)和静脉滴注(43.4%);涉及的药品品种共有47种,其中抗感染药物15种(31.9%),37例(44.6%),位居首位;ADR临床表现主要为皮肤及其附件损害(36.1%)和消化系统损害(20.5%)。结论:应进一步加强对医务人员的宣传教育,积极开展有针对性的培训,强化医务人员上报ADR的意识,并掌握正确填报ADR报表的方法,确保患者用药安全。

OBJECTIVE：To investigate the characteristics and regularity of adverse drug reactions（ADR） in a university hospital and to promote rational use of drugs in the clinic.METHODS：83 ADR cases occurred in 2008-2009 were analyzed in respect of gender and age of patients,route of administration,category of drugs,organs and systems involved in ADR and its clinical manifestation.RESULTS：Of the 83 ADR cases,female cases and male cases were approximately of the same level.The ADRs were mainly caused by oral administration（51.8%） and intravenous drip infusion（43.4%）.47 kinds of drugs were involved,in which antibiotics took up the dominate place,including 37 cases（44.6%） in 15 kinds（31.9%）.The most common clinical symptom represented as lesion of skin and its appendants（36.1%） and lesion of digestive system（20.5%）.CONCLUSION：It is suggested to strengthen the deucation of medical stalf,develop relevant training,enharce the awareness of medical statf on ADR report and master right way to fill in ADR report form to ensure the safety of drug use of patients.