摘要
目的:比较2种根除幽门螺杆菌(Hp)方案的优劣。方法:将197例因各种上消化道症状行胃镜检查并14C-尿素呼气阳性的患者,随机分为A、B组(均符合根除Hp的条件及排除条件)。A组109例,给予雷贝拉唑10mg,阿莫西林-克拉维酸钾分散片(2:1)2片,甲硝唑0.4g;B组88例,给予雷贝拉唑10mg,阿莫西林1g,甲硝唑0.4g。2组给药方法均为每日2次,连用7d。总疗程结束后2周,再行内镜和14C-尿素呼气试验,判断Hp的根除效果。结果:A组根除率为88.07%,B组为73.90%。2组比较,差异有统计学意义(P<0.05)。结论:2种根除Hp的方案中,A组Hp根除率显著高于B组。
OBJECTIVE：To compare 2 kinds of Helicobacter pylori（Hp） eradication program in order to explore the pros and cons of program.METHODS：197 patients underwent gastroscopy because of a variety of upper gastrointestinal symptoms and the rapid urease endoscopy test-positive were randomly divided into 2 groups（in accordance with the conditions for eradication of Hp and exclusion criteria）.109 patients in group A received rabeprazole 10 mg,amoxicillin clavulanate potassium dispersible tablet（2：1） 2 pieces,metronidazole 0.4 g;88 patients in group B received rabeprazole 10 mg,amoxicillin 1 g,metronidazole 0.4 g twice a day for a week.2 weeks after treatment,endoscopy and 14C-urea breath test were conducted again to determine the effect of Hp eradication.RESULTS：The eradication rate was 88.07% in group A and 73.90% in group B.There were significant differences（P〈0.05）.CONCLUSION：The Hp eradication rate is statistically significant between 2 groups.Hp eradication rate of group A is significantly higher than that of group B.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第4期327-328,共2页
China Pharmacy
关键词
阿莫西林-克拉维酸钾
幽门螺杆菌
根除
Amoxicillin clavulanate potassium
Helicobacter pylori
Eradication
