生脉注射液对多发伤患者细胞免疫功能的调节作用

Regulation Effect of Shengmai Injection on Cellular Immune Function in Multiple Trauma Patients

目的:探讨生脉注射液对多发伤患者细胞免疫功能的影响。方法:42例多发伤患者随机分为常规组和生脉组,各21例。常规组采用常规基础治疗,生脉组在常规治疗基础上加用生脉注射液。于治疗前及治疗后第14天测定外周血T淋巴细胞亚群CD4+、CD8+、干扰素-γ(IFN-γ)和白细胞介素-4(IL-4)。另外,治疗后42例多发伤患者(多发伤组)与21例健康志愿者(健康对照组)进行外周血T淋巴细胞亚群、IFN-γ和IL-4比较。结果:多发伤组外周血CD4+、CD8+、CD4+/CD8+比值、IFN-γ及IFN-γ/IL-4比值较健康对照组降低,差异有统计学意义(P<0.01);IL-4较健康对照组升高,差异有统计学意义(P<0.01)。治疗后14d,生脉组CD4+、CD4+/CD8+比值、IFN-γ、IFN-γ/IL-4比值较常规组升高,差异有统计学意义(P<0.05或P<0.01);IL-4的表达较常规组降低,差异有统计学意义(P<0.01)。结论:生脉注射液能够改善多发伤患者细胞免疫功能的紊乱状态。

OBJECTIVE：To investigate regulation effect of Shengmai injection on cellular immune function in multiple trauma patients.METHODS：42 patients with multiple traumas were randomly divided into conventional group and Shengmai group.2 groups were treated conventionally,and Shengmai group was additionally given Shengmai injection.The venous bloods of two groups were collected before treatment and 14th days after treatment.The T-lymphocyte subset,interferon-γ（IFN-γ） and interleukin-4（IL-4） were tested.Besides,after treatment for 14 d,the multiple trauma patients（n=42） and the normal volunteers（n=21） were also matched with the items above.RESULTS：Serum concentration of CD4^＋,CD8^＋,CD4^＋/CD8^＋,IFN-γ and IFN-γ/IL-4 levels in multiple trauma group were significantly lower than in normal control group,there was statistical significance（P〈0.01）.The level of IL-4 in multiple trauma group was significantly higher than normal control group（P〈0.01）.At the 14th day after treatment,serum concentration of CD4^＋,CD4^＋/CD8^＋,IFN-γ and IFN-γ/IL-4 levels in Shengmai group were significantly higher than in conventional group（P〈0.05 or P〈0.01）;the level of IL-4 in Shengmai group was significantly lower than in conventional group（P〈0.01）.CONCLUSION：Shengmai injection can improve the cellular immune function in multiple trauma patients.