摘要
目的:观察不同剂量氢氯噻嗪(HCTZ)对原发性高血压患者肾素-血管紧张素-醛固酮系统(RAAS)活性及生化指标的影响。方法:选择2009年1月-2010年7月在我院治疗的120例轻、中度高血压患者,随机分为3组:对照组(A组)、HCTZ12.5mg组(B组)和HCTZ25.0mg组(C组)。A组:给予苯磺酸氨氯地平5mg,口服,qd;B组:在A组基础上加用HCTZ12.5mg,口服,qd;C组:在A组基础上加用HCTZ25.0mg,口服,qd。6周后比较各组患者血清RAAS活性和生化指标。结果:B组的血管紧张素Ⅱ(AngⅡ)和醛固酮(ALD)浓度较A组高(P<0.05),血钾、血钠浓度下降不明显,血糖未见明显变化(P>0.05);C组血浆肾素(PRA)、AngⅡ和ALD较B组高(P<0.05),血钾、血钠浓度下降,血糖增高。结论:12.5mg的HCTZ即能激活RAAS活性,25.0mg的HCTZ对生化指标有较大影响。
OBJECTIVE:To observe the effects of different concentrations hydrochlorothiazide on variety of renin-angiotensin-aldosterone system and biochemical parameters in hypertensive patients.METHODS:120 cases with mild to moderate hypertension received medical treatment in our hospital during 2009.1-2010.7 They were randomly divided into 3 groups:control group(group A),HCTZ 12.5 mg group(group B) and HCTZ 25.0 mg group(group C).A group:40 patients received 5 mg amlodipine,oral once every day;group B:5 mg amlodipine+12.5 mg HCTZ;group C:5 mg amlodipine +25.0 mg HCTZ.After 6 weeks,the RAAS activity and biochemical parameters of 3 groups were compared.RESULTS:The AngⅡ and ALD in serum of group B after treatment was higher than that of group A(P〈0.05).Serum potassium,serum sodium and blood glucose did not change significantly.The AngⅡand ALD in serum of group C was higher than that of group B(P〈0.05).Serum potassium and serum sodium was lower.Blood glucose was higher.CONCLUSION:12.5 mg HCTZ can activate the RAAS activity and 25.0 mg HCTZ has greater effect to biochemical parameters.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第4期352-354,共3页
China Pharmacy