我国婴儿维生素K缺乏性出血症的病例对照研究

An Case-control Study on Risk Factors of lnfants Vitamin K Deficiency Bleeding.

目的 探讨我国婴儿维生素K 缺乏性出血症发生的危险因素。 方法 采用1∶2 配对的病例一对照研究,收集病例76 例。 结果 婴儿出生后使用维生素K 进行预防、添加辅食及生后2 周患肝炎、腹泻等疾病与出血间关系显著,其OR 值分别为0 .16 、0 .10 、10 .86 。 结论 提倡母乳喂养的同时,为预防婴儿维生素K 缺乏性出血症的发生,应重视推广婴儿生后维生素K

Objective To evaluate the risk factors of infants vitamin K deficiency bleeding(VKDB). Methods A case-control study(1∶2 matched)was undertaken in 7 provinces of China from lst Jan, 1996 to 30th Dec,1997. Results The vitamin K prophylaxis at birth and formula-fed were protective factors, the ORs were 0.16,0.10 respectively,and the mean risk factor to VKDB was the disease of infants in 2 weeks after birth (such as severe liver disease,diarrhea and pneumonia et al),OR being 10.86. Conclusion vitamin K prophylaxis should be propagated.